Substrate: Beta-2 adrenergic receptor (Protein G coupled receptor)
Seq-ID: P04274 [Mesocricetus auratus]
Download:fasta csv
Interaction Network(s): -
External Source(s):
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein homodimerization activity,
norepinephrine binding,
beta2-adrenergic receptor activity		 plasma membrane,
receptor complex,
integral to membrane		 positive regulation of MAPKKK cascade,
receptor-mediated endocytosis,
activation of adenylate cyclase activity,
desensitization of G-protein coupled receptor protein signaling pathway by arrestin
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 132 ETLCVIAVDRYIAITSPFKYQ INSR 8557631
LTP
1.00
 - 7tm_1
0.01
 - medium
Y 132 ETLCVIAVDRYIAITSPFKYQ IGF1R 8910597
LTP
1.00
 - 7tm_1
0.01
 - medium
Y 141 RYIAITSPFKYQSLLTKNKAR - 8521811
LTP
1.00
 - 7tm_1
0.02
 - medium
Y 141 RYIAITSPFKYQSLLTKNKAR INSR 8557631
LTP
1.00
 - 7tm_1
0.02
 - medium
Y 350 LCLRRSSSKAYGNGYSSNSNG - 8521811
LTP
0.10
 GRB2 SH2 -
0.30
 - medium
Y 350 LCLRRSSSKAYGNGYSSNSNG INSR 8557631
LTP
0.10
 GRB2 SH2 -
0.30
 - medium
Y 354 RSSSKAYGNGYSSNSNGKTDY - 8521811
LTP
0.08
 - -
0.42
 - medium
Y 354 RSSSKAYGNGYSSNSNGKTDY INSR 8557631
LTP
0.08
 - -
0.42
 - medium
Y 364 YSSNSNGKTDYMGEASGCQLG - 8521811
LTP
0.15
 - -
0.39
 - medium
Y 364 YSSNSNGKTDYMGEASGCQLG INSR 8557631
LTP
0.15
 - -
0.39
 - medium
S 369 NGKTDYMGEASGCQLGQEKES GRK_group 8132675
LTP
0.16
 - -
0.42
 - medium
S 379 SGCQLGQEKESERLCEDPPGT GRK_group 8132675
LTP
0.72
 - -
0.46
 - medium
T 389 SERLCEDPPGTESFVNCQGTV GRK_group 8132675
LTP
0.45
 - -
0.37
 - medium
S 391 RLCEDPPGTESFVNCQGTVPS GRK_group 8132675
LTP
0.23
 - -
0.35
 - medium
S 406 QGTVPSLSLDSQGRNCSTNDS GRK_group 8132675
LTP
0.44
 - -
0.43
 - medium
S 412 LSLDSQGRNCSTNDSPL     GRK_group 8132675
LTP
0.44
 - -
0.48
 - medium
T 413 SLDSQGRNCSTNDSPL      GRK_group 8132675
LTP
0.93
 - -
0.49
 - medium
S 416 SQGRNCSTNDSPL         GRK_group 8132675
LTP
0.00
 - -
0.44
 - medium

Substrate: Beta-2 adrenergic receptor (Protein G coupled receptor)
Seq-ID: P07550 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-1796656   NHRF1_HUMAN
MINT-4051815   SRC_HUMAN
MINT-7291631   UBP33_HUMAN
MINT-7720120   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
potassium channel regulator activity,
protein homodimerization activity,
norepinephrine binding,
beta2-adrenergic receptor activity		 receptor complex,
endosome,
integral to plasma membrane,
lysosome		 positive regulation of MAPKKK cascade,
receptor-mediated endocytosis,
activation of transmembrane receptor protein tyrosine kinase activity,
endosome to lysosome transport,
desensitization of G-protein coupled receptor protein signaling pathway by arrestin
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 132 ETLCVIAVDRYFAITSPFKYQ IGF1R 8910597
LTP
1.00
 - 7tm_1
0.01
 2R4R 24.02%
Y 141 RYFAITSPFKYQSLLTKNKAR IGF1R 8910597
LTP
1.00
 - 7tm_1
0.01
 2R4R 13.10%
S 246 SEGRFHVQNLSQVEQDGRTGH - 17525332
HTP
0.18
 - 7tm_1
0.31
 --
S 262 GRTGHGLRRSSKFCLKEHKAL - 8083204
LTP
1.00
 MOD_PKA_1
 - 7tm_1
0.20
 --
S 262 GRTGHGLRRSSKFCLKEHKAL PKA_group 11146000
LTP
1.00
 MOD_PKA_1
 - 7tm_1
0.20
 --
Y 326 YVNSGFNPLIYCRSPDFRIAF - 7559596
LTP
0.99
 - TRANS
0.06
 2R4R 8.30%
S 345 AFQELLCLRRSSLKAYGNGYS - 8083204
LTP
0.14
 MOD_PKA_1
 - -
0.08
 2R4R 83.61%
S 345 AFQELLCLRRSSLKAYGNGYS PKA_group 11146000
LTP
0.14
 MOD_PKA_1
 - -
0.08
 2R4R 83.61%
S 346 FQELLCLRRSSLKAYGNGYSS - 8083204
LTP
0.18
 MOD_PKA_1
 - -
0.10
 2R4R 28.69%
S 346 FQELLCLRRSSLKAYGNGYSS PKA_group 11146000
LTP
0.18
 MOD_PKA_1
 - -
0.10
 2R4R 28.69%
S 346 FQELLCLRRSSLKAYGNGYSS PKB_group 11809767
LTP
0.18
 MOD_PKA_1
 - -
0.10
 2R4R 28.69%
S 355 SSLKAYGNGYSSNGNTGEQSG GRK_group 14722251
LTP
0.13
 - -
0.42
 --
S 356 SLKAYGNGYSSNGNTGEQSGY GRK_group 14722251
LTP
0.04
 - -
0.42
 --
T 384 NKLLCEDLPGTEDFVGHQGTV GRK-2 8662852
LTP
0.67
 - -
0.31
 --
T 384 NKLLCEDLPGTEDFVGHQGTV GRK-5 8662852
LTP
0.67
 - -
0.31
 --
T 393 GTEDFVGHQGTVPSDNIDSQG GRK-5 8662852
LTP
0.19
 - -
0.50
 --
S 396 DFVGHQGTVPSDNIDSQGRNC GRK-2 8662852
LTP
0.08
 - -
0.50
 --
S 396 DFVGHQGTVPSDNIDSQGRNC GRK-5 8662852
LTP
0.08
 - -
0.50
 --
S 401 QGTVPSDNIDSQGRNCSTNDS GRK-2 8662852
LTP
0.24
 - -
0.53
 --
S 401 QGTVPSDNIDSQGRNCSTNDS GRK-5 8662852
LTP
0.24
 - -
0.53
 --
S 407 DNIDSQGRNCSTNDSLL     GRK-2 8662852
LTP
0.21
 - -
0.44
 --
S 407 DNIDSQGRNCSTNDSLL     GRK-5 8662852
LTP
0.21
 - -
0.44
 --
S 411 SQGRNCSTNDSLL         GRK-5 8662852
LTP
0.00
 - -
0.34
 --

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